- The signaling mechanisms involved in patterning tissues and directing cell fate in the developing embryo.
- The primary focus of my research is how regulation of primary cilium length impacts Hedgehog signaling in the neural tube and developing limbs of the mouse embryo. I use a cell culture system to assay changes in Hedgehog signaling response when genes involved in cilia production and maintanace are altered. I also study the genetic interaction of these genes and the effect on the length and structure of cilia within specific tissues of the developing mouse embryo.
- In addition, I study the role of Nodal signaling in left-right patterning of the developing mouse embryo.
- The mechanosensory and signaling mechanisms regulating the length and placement of cilia lining the ventricles of the postnatal mouse brain.
NIH Training Grant Trainee 2014-2016
Gilliland WD, Colwell EM, Lane FM, Snouffer AA. Behavior of aberrant chromosome configurations in Drosophila melanogaster female meiosis I. G3 2014 Dec 9;5(2):175-82
Rea AC, Vandenberg LN, Ball RE, Snouffer AA, Hudson AG, Zhu Y, McLain DE, Johnston LL, Lauderdale JD, Levin M, Dore TM. Light-activated serotonin for exploring its action in biological systems.Chem Biol. 2013 Dec 19;20(12):1536-46