- The signaling mechanisms involved in patterning tissues and directing cell fate in the developing embryo.
- The primary focus of my research is how regulation of primary cilium length impacts Hedgehog signaling in the neural tube and developing limbs of the mouse embryo. I use a cell culture system to assay changes in Hedgehog signaling response when genes involved in cilia production and maintanace are altered. I also study the genetic interaction of these genes and the effect on the length and structure of cilia within specific tissues of the developing mouse embryo.
- In addition, I study the role of Nodal signaling in left-right patterning of the developing mouse embryo.
- The mechanosensory and signaling mechanisms regulating the length and placement of cilia lining the ventricles of the postnatal mouse brain.
NIH Training Grant Trainee 2014-2016
Linton and June Bishop Graduate Fellowship
Snouffer A*, Brown D*, Lee H*, Walsh J, Lupu F, et al. (2017) Cell Cycle-Related Kinase (CCRK) regulates ciliogenesis and Hedgehog signaling in mice. PLOS Genetics 13(8): e1006912 *co-first authors
Gilliland WD, Colwell EM, Lane FM, Snouffer AA. (2014) Behavior of aberrant chromosome configurations in Drosophila melanogaster female meiosis I. G3 9;5(2):175-82
Rea AC, Vandenberg LN, Ball RE, Snouffer AA. Hudson AG, Zhu Y, McLain DE, Johnston LL, Lauderdale JD, Levin M, Dore TM. (2013) Light-activated serotonin for exploring its action in biological systems.Chem Biol.19;20(12):1536-46