Assistant Professor
Ph.D. (1998) Columbia University, New York
  • Research Interests -
    • Our laboratory is interested in the mechanisms controlling tissue patterning during mammalian embryonic development. Using the mouse as a model, we exploit a combination of reverse and forward genetic approaches to investigate signaling pathways that function in cell fate specification in different contexts. Our work has primarily focused on identification of novel regulators of the Hedgehog signaling pathway acting within the developing central nervous system. In addition, we have recently begun to examine the regulation of Nodal signaling in the control of patterning along the left-right axis of the mouse embryo. Building upon our genetic analyses, we are working to elucidate the specific functions of these novel regulatory factors at the cellular and biochemical levels.
Selected Publications: 
  • Nishio M., K. Hamada, K. Kawahara, M. Sasaki, F. Noguchi, S. Chiba, K. Mizuno, S.O. Suzuki, Y. Dong, M. Tokuda, T. Morikawa, H. Hikasa, J.T. Eggenschwiler, N. Yabuta, N. Nojima, K. Nakagawa, Y. Hata, H. Nishina, K. Mimori, M. Mori, T. Sasaki, T.W. Mak, T. Nakano, S. Itami and A. Suzuki. 2012. Cancer susceptibility and embryonic lethality in Mob1A/1B double mutant mice. J. Clin. Invest 122(12): 4505-18.
  • Eggenschwiler J.T. 2012. Hedgehog signaling and the cilium: in the zone. Dev Cell. 23: 677-8.
  • Ochbina P.J.R., J.T. Eggenschwiler, I. Moskowitz and K.V. Anderson. 2011. Complex Interactions Between Genes Controlling Trafficking in Primary Cilia. Nat. Genet. 43: 547-53.
  • Qin, J., Y. Lin, H.W. Ko and J.T. Eggenschwiler. 2011. IFT122 antagonizes Sonic Hedgehog signaling and controls ciliary localization of pathway components. Proc. Natl. Acad. Sci. 108: 1456-61.
  • Ko H.W., R.X. Norman, J. Tran, K.P. Fuller, M. Fukuda and J.T. Eggenschwiler. 2010. Broad-minded links cell cycle-related kinase to cilia assembly and Hedgehog signal transduction. Dev. Cell 18: 237-247.
  • Walczak-Sztulpa J., J.T. Eggenschwiler, D. Osborn, D. Brown, F. Emma, C. Klingenberg, R.C. Hennekam, T. Giuliano, M. Garshasbi, A. Tzschach, M. Szczepanska, M. Krawczynski, J. Zachwieja, Zwolinska, P.L. Beales, H. Ropers, A. Latos-Bielenska and A. Kuss. 2010. Cranioectodermal dysplasia (Sensenbrenner Syndrome) is a ciliopathy caused by mutations in the IFT122 gene. Am. J. Hum. Genet. 86: 949-56.
  • Norman R.X., H.W. Ko, V. Huang, C.M. Eun, L.L. Abler, Z. Zhang, X. Sun and J.T. Eggenschwiler. 2009. Tubby-like protein 3 (TULP3) regulates patterning in the mouse embryo through inhibition of Hedgehog signaling. Hum. Mol. Genet. 18: 1740-54.
  • Ko H.W., A. Liu and J.T. Eggenschwiler. 2009. Analysis of hedgehog signaling in mouse intraflagellar transport mutants. Meth. Cell Biol. Vol. 93. Eds: King, S.M. and Pazour, G.P. ISBN: 978-0-12-381377-0
  • Cho A., H.W. Ko and J.T. Eggenschwiler. 2008. FKBP8 cell-autonomously controls neural tube patterning through a Gli2- and Kif3a-dependent mechanism. Dev. Biol. 321: 27-39.
  • Eggenschwiler J.T. and K.V. Anderson. 2007. Cilia and Developmental Signaling. Ann. Rev. Cell Dev. Biol. 23: 345-73.
  • Eggenschwiler, J.T., J. Qin, O. Bulgakov, T. Li and K.V. Anderson. 2006. Mouse Rab23 regulates Hedgehog signaling from Smoothened to Gli proteins. Dev. Biol. 290: 1-12.
  • Garcia-Garcia, M.J., J.T. Eggenschwiler, T. Caspary, H.L. Alcorn, M.W. Wyler, D. Huangfu, A.S. Rakeman, J.D. Lee, E.H. Feinberg, J.R. Timmer and K.V. Anderson. 2005. Analysis of mouse embryonic patterning and morphogenesis by forward genetics. Proc. Natl. Acad. Sci. 102: 5913-9.
  • Bulgakov, O.V. *, J.T. Eggenschwiler*, D. Hong, K.V. Anderson and T. Li. 2004. FKBP8 is a neural-specific negative regulator of Sonic hedgehog signaling. Development 131: 2149-59. * Equal contribution
  • Caspary, T., M.J. Garcia-Garcia, D. Huangfu, J.T. Eggenschwiler, M.W. Wyler, A.S. Rakeman, H.L. Alcorn and K.V. Anderson. 2002. Mouse Dispatched homologue1 is required for long-range but not juxtacrine Hh signaling. Curr. Biol. 12: 1628-32.
  • Eggenschwiler, J.T., E. Espinoza and Anderson, K.V. 2001. Rab23 is an essential negative regulator of the mouse Sonic hedgehog signaling pathway. Nature 412: 194-8.
  • Eggenschwiler, J.T. and K. Anderson. 2000. Dorsal and lateral fates in the mouse neural tube require the cell-autonomous activity of the open brain gene. Dev. Biol. 227: 648-660.
  • Eggenschwiler, J.T., T. Ludwig, P. Fisher, P. Leighton, S. Tilghman and A. Efstratiadis. 1997. Mouse mutant embryos overexpressing IGF-II exhibit phenotypic features of the Beckwith-Wiedemann and Simpson-Golabi-Behmel syndromes. Genes Dev. 11: 3128-3142.
  • Ludwig, T., J. Eggenschwiler, P. Fisher, A.J. D'Ercole, M.L. Davenport and A. Efstratiadis. 1996. Mouse mutants lacking the type 2 IGF receptor (IGF2R) are rescued from perinatal lethality in Igf2 and Igf1r null backgrounds. Dev. Biol. 177: 517-35.
  • Leighton, P.A., R.S. Ingram, J. Eggenschwiler, A. Efstratiadis and S.M. Tilghman. 1995. Disruption of imprinting caused by deletion of the H19 gene region in mice. Nature 375: 34-9.
Research Interests Detail: 

Mammalian developmental genetics: mechanisms that control tissue patterns during mammalian embryonic development; signaling pathways that function in cell fate specification; identification of novel regulators of Hedgehog signaling pathways in central nervous system