Distinguished Research Professor
Ph.D. (1973) Yale University
M. Phil. (1971) Yale University
B.S. (1969) University of Illinois

Contact

meagher@uga.edu
  • Fellow, The American Association for the Advancement of Science
  • Inventor's Award, University of Georgia, 2004
  • Lamar Dodd Award for Research, University of Georgia, 2001
  • Creative Research Medal, University of Georgia, 1987
  • Grant Support -
    • "Differential Expression of Diverse Actin Genes in Higher Plants," NIH
  • Research Interests -
    • Epigenetic reprogramming in humans and mammalian models in response to the environment (e.g., diet, exercise, stress, sleep, carcinogens) and the epigenome induced risk of disease (i.e., cancer, cardiovascular disease, metabolic syndrome, obesity). We have a strong interest in performing cell-type-specific epigenetic analyses on organs composed of complex mixtures of cell types including blood, brain, adipose tissues, and the placenta. Recent projects center on translational epigenetics applied to obesity, and in particular, retarding adipogenesis and lipogenesis.
Research Interests:

Molecular evolutionary genetics of gene families and phytoremediation: molecular genetics and evolution of plant gen expression; environmental molecular biology; actin and actin-binding proteins encoded by gene families in plants; subfamilies of encoded protein isovariants co-evolved specific interactions in tissues and organs of Arabidopsis; develop plant-based production and delivery systems for biopesticides to kill mosquito/fly larvae

Selected Publications:

(see Google Scholar for a complete list of peer reviewed publications)

Ambati, S., Yu, P., McKinney, E.C., Kandasamy, M., Hartzell, D., Baile, C.A., and Meagher, R.B. (2016). Adipocyte nuclei captured from VAT and SAT BMC Obesity 3, 1-19.

Hohos, N.M., Lee, K., Ji, L., Yu, M., Kandasamy, M.M., Phillips, B.G., Baile, C.A., He, C., Schmitz, R.J., and Meagher, R.B. (2016). DNA cytosine hydroxymethylation levels are distinct among non-overlapping classes of peripheral blood leukocytes. J Immunol Methods 436, 1-15. http://www.ncbi.nlm.nih.gov/pubmed/27164004.

Miller, C.N., Yu, P., Ambati, S., McKinney, E.C., Avra, T., Baile, C.A., and Meagher, R.B. (2016). UCP1 in sebaceous glands corresponds with increased antioxidant potential and not brown adipose tissue function. Exp Dermatol 25, 563-5. http://www.ncbi.nlm.nih.gov/pubmed/26914475.

Yu, P., Ji, L., Lee, K.J., Yu, M., He, C., Ambati, S., McKinney, E.C., Jackson, C., Baile, C.A., Schmitz, R.J., and Meagher, R.B. (2016). Subsets of Visceral Adipose Tissue Nuclei with Distinct Levels of 5-Hydroxymethylcytosine. PLoS One 11, e0154949. http://www.ncbi.nlm.nih.gov/pubmed/27171244.

Gan, L., England, E., Yang, J.Y., Toulme, N., Ambati, S., Hartzell, D.L., Meagher, R.B., and Baile, C.A. (2015). A 72-hour high fat diet increases transcript levels of the neuropeptide galanin in the dorsal hippocampus of the rat. BMC Neurosci 16, 51. http://www.ncbi.nlm.nih.gov/pubmed/26260473.

Kandasamy, M.K., McKinney, E.C., Roy, E., and Meagher, R.B. (2015). Ascomycete Fungal Actins Differentially Support Plant Spatial Cell and Organ Development. Cytoskeleton. (Hoboken) 72, 80-92. http://www.ncbi.nlm.nih.gov/pubmed/25428798.

Mussar, K.J., Kandasamy, M.K., McKinney, E.C., and Meagher, R.B. (2015). Arabidopsis plants deficient in constitutive class profilins reveal independent and quantitative genetic effects. BMC Plant Biol 15, 177. http://www.ncbi.nlm.nih.gov/pubmed/26160044.

Roy-Zokan, E.M., Dyer, K.A., and Meagher, R.B. (2015). Phylogenetic Patterns of Codon Evolution in the ACTIN-DEPOLYMERIZING FACTOR/COFILIN (ADF/CFL) Gene Family. PLoS One 10, e0145917. http://www.ncbi.nlm.nih.gov/pubmed/26717562.

Meagher, R.B. (2014). 'Memory and molecular turnover,' 30 years after inception. Epigenetics Chromatin 7, 37. http://www.ncbi.nlm.nih.gov/pubmed/25525471.

Yu, P., McKinney, E.C., Kandasamy, M.M., Albert, A.L., and Meagher, R.B. (2015). Characterization of brain cell nuclei with decondensed chromatin. Dev Neurobiol 75, 738-56. http://www.ncbi.nlm.nih.gov/pubmed/25369517.

Gan, L., England, E., Yang, J.Y., Toulme, N., Ambati, S., Hartzell, D.L., Meagher, R.B., and Baile, C.A. (2015). A 72-hour high fat diet increases transcript levels of the neuropeptide galanin in the dorsal hippocampus of the rat. BMC Neurosci 16, 51. http://www.ncbi.nlm.nih.gov/pubmed/26260473.

Meagher, R.B. (2014) Rapid production of monoclonal antibodies. U.S. Patent.

Ambati, S., Yu, P., McKinney, E.C., Kandasamy, M., Hartzell, D., Baile, C.A., and Meagher, R.B. (2016). Adipocyte nuclei captured from VAT and SAT BMC Obesity 3, 1-19.

Hohos, N.M., Lee, K., Ji, L., Yu, M., Kandasamy, M.M., Phillips, B.G., Baile, C.A., He, C., Schmitz, R.J., and Meagher, R.B. (2016). DNA cytosine hydroxymethylation levels are distinct among non-overlapping classes of peripheral blood leukocytes. J Immunol Methods 436, 1-15. http://www.ncbi.nlm.nih.gov/pubmed/27164004.

Miller, C.N., Yu, P., Ambati, S., McKinney, E.C., Avra, T., Baile, C.A., and Meagher, R.B. (2016). UCP1 in sebaceous glands corresponds with increased antioxidant potential and not brown adipose tissue function. Exp Dermatol 25, 563-5. http://www.ncbi.nlm.nih.gov/pubmed/26914475.

Yu, P., Ji, L., Lee, K.J., Yu, M., He, C., Ambati, S., McKinney, E.C., Jackson, C., Baile, C.A., Schmitz, R.J., and Meagher, R.B. (2016). Subsets of Visceral Adipose Tissue Nuclei with Distinct Levels of 5-Hydroxymethylcytosine. PLoS One 11, e0154949. http://www.ncbi.nlm.nih.gov/pubmed/27171244.

Gan, L., England, E., Yang, J.Y., Toulme, N., Ambati, S., Hartzell, D.L., Meagher, R.B., and Baile, C.A. (2015). A 72-hour high fat diet increases transcript levels of the neuropeptide galanin in the dorsal hippocampus of the rat. BMC Neurosci 16, 51. http://www.ncbi.nlm.nih.gov/pubmed/26260473.

Kandasamy, M.K., McKinney, E.C., Roy, E., and Meagher, R.B. (2015). Ascomycete fungal actins differentially support plant spatial cell and organ development. Cytoskeleton (Hoboken) 72, 80-92. http://www.ncbi.nlm.nih.gov/pubmed/25428798.

Mussar, K.J., Kandasamy, M.K., McKinney, E.C., and Meagher, R.B. (2015). Arabidopsis plants deficient in constitutive class profilins reveal independent and quantitative genetic effects. BMC Plant Biol 15, 177. http://www.ncbi.nlm.nih.gov/pubmed/26160044.

Roy-Zokan, E.M., Dyer, K.A., and Meagher, R.B. (2015). Phylogenetic Patterns of Codon Evolution in the ACTIN-DEPOLYMERIZING FACTOR/COFILIN (ADF/CFL) Gene Family. PLoS One 10, e0145917. http://www.ncbi.nlm.nih.gov/pubmed/26717562.

Yu, P., McKinney, E.C., Kandasamy, M.M., Albert, A.L., and Meagher, R.B. (2015). Characterization of brain cell nuclei with decondensed chromatin. Dev Neurobiol 75, 738-56. http://www.ncbi.nlm.nih.gov/pubmed/25369517.

Gan, L., England, E., Yang, J.Y., Toulme, N., Ambati, S., Hartzell, D.L., Meagher, R.B., and Baile, C.A. (2015). A 72-hour high fat diet increases transcript levels of the neuropeptide galanin in the dorsal hippocampus of the rat. BMC Neurosci 16, 51. http://www.ncbi.nlm.nih.gov/pubmed/26260473.

Meagher, R.B. (2014). Rapid production of monoclonal antibodies, U.S. Patent. #8912385 http://www.freepatentsonline.com/8912385.html.

Kandasamy, M.K., McKinney, E.C., Roy, E., and Meagher, R.B. (2012). Plant vegetative and animal cytoplasmic actins share functional competence for spatial development with protists. Plant Cell 24, 2041-57. http://www.ncbi.nlm.nih.gov/pubmed/22589468.

Leblanc, M.S., McKinney, E.C., Meagher, R.B., and Smith, A.P. (2012). Hijacking membrane transporters for arsenic phytoextraction. J Biotechnol http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=23108027.

Meagher, R.B., and Mussar, K.J. (2012). The Influence of DNA Sequence on Epigenome-Induced Pathologies. Epigenetics Chromatin 5, 11-35. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=22818522.

Stead, M.B., Agrawal, A., Bowden, K.E., Nasir, R., Mohanty, B.K., Meagher, R.B., and Kushner, S.R. (2012). RNAsnap: a rapid, quantitative and inexpensive, method for isolating total RNA from bacteria. Nucleic Acids Res 40, e156. http://www.ncbi.nlm.nih.gov/pubmed/22821568.

Henty, J.L., Bledsoe, S.W., Khurana, P., Meagher, R.B., Day, B., Blanchoin, L., and Staiger, C.J. (2011). Arabidopsis actin depolymerizing factor4 modulates the stochastic dynamic behavior of actin filaments in the cortical array of epidermal cells. Plant Cell 23, 3711-26. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=22010035.

Shoreibah, M.G., Jackson, C.L., Price, P.W., Meagher, R., Godwin, A.K., Cai, Q., and Gildersleeve, J.C. (2011). Anti-human embryonic stem cell monoclonal antibody hesca-2 binds to a glycan epitope commonly found on carcinomas. Stem Cells Dev 20, 515-25. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=20887211.

Kandasamy, M.K., McKinney, E.C., and Meagher, R.B. (2010). Differential sublocalization of actin variants within the nucleus. Cytoskeleton (Hoboken) 67, 729-43. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=20862689.

Meagher, R.B. (2010a). The evolution of epitype. Plant Cell 22, 1658-66. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=20551346.

Meagher, R.B. (2010b) Conditional sterility in plants U.S. PATENT. 7,667,096.

Smith, A.P., Jain, A., Deal, R.B., Nagarajan, V.K., Poling, M.D., Raghothama, K.G., and Meagher, R.B. (2010). Histone H2A.Z regulates the expression of several classes of phosphate starvation response genes but not as a transcriptional activator. Plant Physiol 152, 217-25. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=19897606.

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