Molecular Genetics

Molecular Genetics Personnel

Genome structure and evolution: rearrangements and contributions of transposable elements; relationship between genome structure, evolution, and gene function; genetic diversity in crops of developing world; evolution of disease resistance in plants

Stem cell biology, somatic cell reprogramming and vertebrate developmental genetics. Defining the key genes and regulatory elements that regulate fetal thymus development in mice; genome editing and epigenome editing (via CRISPR).

Cytogenetics of chromosome movement: motility of chromosomes in maize

Mammalian developmental genetics: mechanisms that control tissue patterns during mammalian embryonic development; signaling pathways that function in cell fate specification; identification of novel regulators of Hedgehog signaling pathways in central nervous system

The Goll laboratory is interested in epigenetics and chromatin regulation in the context of development and disease. We exploit a combination of genetic, genomic, molecular and cell biology based approaches to ask these questions using zebrafish as our primary model.

Systems biology of host-pathogen interactions, Genome evolution in eukaryotic parasites, Databases, Ontologies, Data mining and Data integration of 'omics (genome, transcriptome, proteome, metabolome, lipidome), clinical, immunological, epidemiological and experimental metadata.  

RNA metabolism; developing a better understanding of the mechanisms involved in processing, maturation, and decay of RNA molecules in E. coli; role of polyadenylation in bacteria; analysis of DNA repair, mutagenesis, and recombination; and biotechnology.

Developmental genetics of vertebrate organogenesis: life history of the thymus (responsible for the generation of T cells); diverse aspects of biology of organ controlled by cellular dynamics, regulatory networks, and physiological processes; organ homeostasis, aging, and regeneration

Telomere maintenance and recombination: telomeres are caps that permit complete replication of chromosome ends; loss of telomere function can lead to carcinogenesis; human cancers emerge with high levels of telomerase; studying telomeres to identify and characterize components and the roles they

Molecular evolutionary genetics of gene families and phytoremediation: molecular genetics and evolution of plant gen expression; environmental molecular biology; actin and actin-binding proteins encoded by gene families in plants; subfamilies of encoded protein isovariants co-evolved specific int

Developmental regulation and evolution of vertebrate morphology: how the expression of limb genes is regulated and to what degree changes in the regulation of limb genes contributes to evolution of divergent limb morphologies; identification of regulatory elements that control expression of limb

Population epigenomics and mechanisms of epigenetic inheritance: molecular mechanisms of DNA methylation initiation and establishment; how phenotypic plasticity and diversity are driven by epigenetic variation; identification of environmentally induced, spontaneous, and natural epigenetic alleles

Non-coding RNA function, cancer, and genome defense: biogenesis, trafficking, and function of non-coding RNA-protein complexes; goal to improve understanding and treatment of human disease

Gene family evolution, cell wall biogenesis, phenylpropanoid metabolism, stress genomics, and bioenergy 

Extremophile biology, biotechnology, and bioenergy: conversion of biomass from crop plants into biofuels; identification, characterization, and manipulation of microorganisms and biocatalysts for biomass conversion; access to new pathways for biomass conversion; ability to genetically manipulate