Molecular Genetics

Molecular Genetics Personnel

Genome structure and evolution: rearrangements and contributions of transposable elements; relationship between genome structure, evolution, and gene function; genetic diversity in crops of developing world; evolution of disease resistance in plants

Neural progenitor cells (NPCs), neural development, and neural degeneration

Stem cell biology and vertebrate developmental genetics: definite genetics pathways that regulate fetal thymus development in mice; new genetic research tools based on site-specific recombination (generate tissues specific genetic modifications)

Translational research in medical oncology, basic science studies of tumor biology/immunology, environmental risk factors and medical education.

Cytogenetics of chromosome movement: motility of chromosomes in maize

Mammalian developmental genetics: mechanisms that control tissue patterns during mammalian embryonic development; signaling pathways that function in cell fate specification; identification of novel regulators of Hedgehog signaling pathways in central nervous system

Systems biology of host-pathogen interactions, Genome evolution in eukaryotic parasites, Databases, Ontologies, Data mining and Data integration of 'omics (genome, transcriptome, proteome, metabolome, lipidome), clinical, immunological, epidemiological and experimental metadata.  

RNA metabolism; developing a better understanding of the mechanisms involved in processing, maturation, and decay of RNA molecules in E. coli; role of polyadenylation in bacteria; analysis of DNA repair, mutagenesis, and recombination; and biotechnology.

Developmental genetics of vertebrate organogenesis: life history of the thymus (responsible for the generation of T cells); diverse aspects of biology of organ controlled by cellular dynamics, regulatory networks, and physiological processes; organ homeostasis, aging, and regeneration

Telomere maintenance and recombination: telomeres are caps that permit complete replication of chromosome ends; loss of telomere function can lead to carcinogenesis; human cancers emerge with high levels of telomerase; studying telomeres to identify and characterize components and the roles they

Molecular evolutionary genetics of gene families and phytoremediation: molecular genetics and evolution of plant gen expression; environmental molecular biology; actin and actin-binding proteins encoded by gene families in plants; subfamilies of encoded protein isovariants co-evolved specific int

Developmental regulation and evolution of vertebrate morphology: how the expression of limb genes is regulated and to what degree changes in the regulation of limb genes contributes to evolution of divergent limb morphologies; identification of regulatory elements that control expression of limb

Evolutionary biology & behaviour genetics; molecular and quantitative genetic studies of complex traits, especially social interactions (parenting, mating behaviour, communication); development of behaviour; theoretical investigations of evolution of social interactions.

Population epigenomics and mechanisms of epigenetic inheritance: molecular mechanisms of DNA methylation initiation and establishment; how phenotypic plasticity and diversity are driven by epigenetic variation; identification of environmentally induced, spontaneous, and natural epigenetic alleles

Non-coding RNA function, cancer, and genome defense: biogenesis, trafficking, and function of non-coding RNA-protein complexes; goal to improve understanding and treatment of human disease

Gene family evolution, cell wall biogenesis, phenylpropanoid metabolism, stress genomics, and bioenergy 

Extremophile biology, biotechnology, and bioenergy: conversion of biomass from crop plants into biofuels; identification, characterization, and manipulation of microorganisms and biocatalysts for biomass conversion; access to new pathways for biomass conversion; ability to genetically manipulate