Professor of Microbiology Ph.D. (1987) Yale University Creative Research Medal, University of Georgia, 2005 Grant Support - “Regulation of Aromatic Compound Degradation in Acinetobacter,” NSF “REU Site: Research in Prokaryotic Biology” NSF Selected Publications Selected Publications: Reams, A.B. and E.L. Neidle. 2004. Gene amplification involves site-specific short homology-independent illegitimate recombination in Acinetobacter sp. strain ADP1. Journal of Molecular Biology 338: 643-656. Buchan, A., Neidle, E.L. and M.A. Moran. 2004. Diverse organization of genes of the beta-ketoadipate pathway in members of the marine Roseobacter lineage. Applied and Environmental Microbiology 70: 1658-1668. Clark, T.J., Phillips, R.S., Bundy, B.M., Momany, C. and E.L. Neidle. 2004. Benzoate decreases the binding of cis,cis-muconate to the BenM regulator despite the synergistic effect of both compounds on transcriptional activation. Journal of Bacteriology 186: 1200-1204. Clark, T., Haddad S., Neidle E.L. and C. Momany. 2004. Crystallization of the effector-binding domains of BenM and CatM, LysR-type transcriptional regulators from Acinetobacter sp. ADP1. Acta Crystallographica. Section D, Biological Crystallography 60: 105-108. Reams, A.B. and E.L. Neidle. 2004. Selection for gene clustering by tandem duplication., Annual Review of Microbiology 58: 119-142. Beharry, Z.M., Eby, D.M., Coulter, E.D., Viswanathan, R., Neidle, E.L., Phillips, R.S. and D.M. Kurtz. 2003. Histidine ligand protonation and redox potential in the Rieske dioxygenases: role of a conserved aspartate in anthranilate 1,2-dioxygenase. Biochemistry 42: 13625-13636. Reams, A.B. and E.L. Neidle. 2003. Genome plasticity in Acinetobacter: new degradative capabilities acquired by the spontaneous amplification of large chromosomal segments, Molecular Microbiology, 47: 1291-304. Brzostowicz, P.C., Reams, A.B., Clark, T.J. and E.L. Neidle. 2003. Transcriptional cross-regulation of the catechol and protocatechuate branches of the beta-ketoadipate pathway contributes to carbon source-dependent expression of the Acinetobacter sp. strain ADP1. Applied and Environmental Microbiology 69: 1598-1606. Cosper, N.J., Eby, D.M., Kounosu, A., Kurosawa, N., Neidle, E.L., Kurtz, D.M., Iwasaki, T. and R.A. Scott. 2002. Redox-dependent structural changes in archaeal and bacterial Rieske-type [2Fe-2S] clusters. Protein Science 11: 2969-2973. Bundy, B.M., Collier, L.S., Hoover T.R. and E.L. Neidle. 2002. Synergistic transcriptional activation by one regulatory protein in response to two metabolites. Proc. Natl. Acad. Sci. USA 99: 7693-7698. Karlsson, A., Beharry, Z.M., Matthew, E.D., Coulter, E.D., Neidle, E.L., Kurtz, D.M., Eklund, H. and S. Ramaswamy. 2002. X-ray crystal structure of benzoate 1,2-dioxygenase reductase from Acinetobacter sp. strain ADP1. Journal of Molecular Biology 318: 261-272. Clark, T.J., Momany, C. and E.L. Neidle. 2002. The benPK operon, proposed to play a role in transport, is part of a regulon for benzoate catabolism in Acinetobacter sp. strain ADP1, Microbiology 148: 1213-1223. Buchan A., Neidle, E.L. and M.A. Moran. 2001. Diversity of the ring-cleaving dioxygenase gene pcaH in a salt marsh bacterial community. Applied and Environmental Microbiology 67: 5801-5809. Haddad, S., Eby, D.M. and E.L. Neidle. 2001. Cloning and expression of the benzoate dioxygenase genes from Rhodococcus sp. strain 19070. Applied and Environmental Microbiology 67: 2507-2514. Eby, D.M., Beharry, Z.M., Coulter, E.D., Kurtz, D.M. and E.L. Neidle. 2001. Characterization and evolution of anthranilate 1,2-dioxygenase from Acinetobacter sp. strain ADP1, Journal of Bacteriology 183: 109-118. Cosper N.J., Collier, L.S., Clark, T.J., Scott, R.A. and E.L. Neidle. 2000. Mutations in catB, the gene encoding muconate cycloisomerase, activate transcription of the distal ben genes and contribute to a complex regulatory circuit in Acinetobacter sp. strain ADP1. Journal of Bacteriology 182: 7044-7052. Buchan, A., Collier, L.S., Neidle, E.L. and M.A. Moran. 2000. Key aromatic-ring-cleaving enzyme, protocatechuate 3,4-dioxygenase, in the ecologically important marine Roseobacter lineage. Applied and Environmental Microbiology 66: 4662-4672.
