Professor of Cellular Biology Ph.D. (1990) University of California, San Diego Associate Editor, BMC Cell Division Creative Research Medal, University of Georgia, 2005 Grant Support - “Genetics of Cell Cycle Regulators in C. elegans”, NIH “Function of the CUL-2 Cell Cycle Regulator in C. elegans”, American Cancer Society Selected Publications Selected Publications: Starostina, N.G., J.M. Simpliciano, M.A. McGuirk and E.T. Kipreos. 2010. CRL2LRR-1 targets a CDK inhibitor for cell cycle control in C. elegans and actin-based motility regulation in human cells. Developmental Cell 19: 753-756. Akella, J.S., D. Wloga, J. Kim, N.G. Starostina, S. Lyons-Abbott, N.S. Morrissette, S.T. Dougan, E.T. Kipreos and J. Gaertig. 2010. MEC-17 is an alpha-tubulin acetyltransferase. Nature 467: 218-22. Bosu, D.R., H. Feng, K. Min, Y. Kim and E.T. Kipreos. 2010. C. elegans CAND-1 regulates cullin neddylation and regulates cell proliferation and morphogenesis in specific tissues. Developmental Biology 346: 113-26. Rahman, M.M., O. Stuchlick, E.G. El-Karim, R.Stuart, E.T. Kipreos and L. Wells. 2010. Intracellular protein glycosylation modulates insulin mediated lifespan in C. elegans. Aging 2: 678-690. Kim, Y., N.G. Starostina and E.T. Kipreos. 2008. The CRL4Cdt2 ubiquitin ligase targets the degradation of p21Cip1 to control replication licensing. Genes & Development 22: 2507-2159. Starostina, N.G., J. Lim, M. Schvarzstein, L. Wells, A.M. Spence and E.T. Kipreos. 2007. A CUL-2 ubiquitin ligase containing three FEM proteins degrades TRA-1 to regulate C. elegans sex determination. Developmental Cell 13: 127-139. Kim, J., H. Feng and E.T. Kipreos. 2007. C. elegans CUL-4 prevents re-replication by promoting the nuclear export of CDC-6 via a CKI-1-dependent pathway. Current Biology 17: 966-972. Vasudevan, S., N.G. Starostina and E.T. Kipreos. 2007. The C. elegans cell cycle regulator ZYG-11 defines a conserved family of CUL-2 complex components. EMBO Reports 8: 279-286. Kim, Y., and E.T. Kipreos. 2007. The C. elegans replication licensing factor CDT-1 is targeted for degradation by the CUL-4/DDB-1 complex. Molecular and Cellular Biology 27: 1394-1406. Kipreos, E.T. 2005. C. elegans cell cycles: invariance and stem cell divisions. Nature Reviews Molecular Cell Biology 6: 766-776. Kipreos, E.T. 2005. Ubiquitin-mediated pathways in C. elegans. WormBook. ed. The C. elegans Research Community, WormBook, doi/10.1895/wormbook.1.7.1, http://www.wormbook.org. Liu, J., S. Vasudevan and E.T. Kipreos. 2004. CUL-2 and ZYG-11 promote meiotic anaphase II and the proper placement of the anterior-posterior axis in C. elegans. Development 131: 3513-3525. Zhong, W., H. Feng, F.E. Santiago and E.T. Kipreos. 2003. CUL-4 ubiquitin ligase maintains genome stability by restraining DNA replication licensing. Nature 423: 885-889. Nayak S., F. Santiago, H. Jin, D. Lin, T. Schedl and E.T. Kipreos. 2002. The Caenorhabditis elegans Skp1-related (skr) gene family: diverse functions in cell proliferation, morphogenesis, and meiosis. Current Biology 12: 277-287. Liu, J. and E.T. Kipreos. 2000. Evolution of cyclin-dependent kinases (CDKs) and CDK-activating kinases (CAKs): Differential conservation of CAKs in yeast and metazoa. Molecular Biology and Evolution 17: 1061-1074. Kipreos, E.T., S.P. Gohel and E.M. Hedgecock. 2000. The C. elegans F-box/WD-repeat protein LIN-23 functions to limit cell division during development. Development 127: 5071-5082. Feng, H., W. Zhong, G. Punkosdy, S. Gu, L. Zhou, E.K. Seabolt and E.T. Kipreos. 1999. CUL-2 is required for the G1-to-S phase transition and mitotic chromosome condensation in Caenorhabditis elegans. Nature Cell Biology 1: 486-492. Kipreos, E.T., L.E. Lander, J.P. Wing, W.W. He and E.M. Hedgecock. 1996. cul-1 is required for cell cycle exit in C. elegans and identifies a novel gene family. Cell 85: 829-839.
